{"id":775263,"date":"2025-12-05T19:47:38","date_gmt":"2025-12-05T18:47:38","guid":{"rendered":"https:\/\/www.hashtag.al\/?p=775263"},"modified":"2025-12-05T19:47:38","modified_gmt":"2025-12-05T18:47:38","slug":"studimi-disa-familje-ne-bote-kane-imunitet-natyral-ndaj-viruseve","status":"publish","type":"post","link":"https:\/\/www.hashtag.al\/index.php\/2025\/12\/05\/studimi-disa-familje-ne-bote-kane-imunitet-natyral-ndaj-viruseve\/","title":{"rendered":"Studimi\/ Disa familje n\u00eb bot\u00eb kan\u00eb imunitet natyral ndaj viruseve","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

\"\"<\/p>\n

S\u00ebmundjet virale mbeten nd\u00ebr shkaqet kryesore t\u00eb s\u00ebmundshm\u00ebris\u00eb dhe vdekshm\u00ebris\u00eb n\u00eb mbar\u00eb bot\u00ebn. Pandemia e gripit t\u00eb vitit 1918 shkaktoi 20\u201350 milion\u00eb viktima vet\u00ebm n\u00eb Evrop\u00eb, dhe viruse t\u00eb tilla vazhdojn\u00eb t\u00eb d\u00ebrgojn\u00eb \u00e7do vit rreth gjysm\u00eb milioni njer\u00ebz n\u00eb spital, duke marr\u00eb dhjet\u00ebra mij\u00ebra jet\u00eb. <\/span><\/p>\n

Pandemia e COVID-19 ka shkaktuar deri n\u00eb 15 milion\u00eb viktima globalisht dhe ende nuk ka p\u00ebrfunduar plot\u00ebsisht. Nd\u00ebrkoh\u00eb, ndryshimet klimatike dhe shkat\u00ebrrimi i habitateve rrisin rrezikun e shfaqjes s\u00eb viruseve t\u00eb reja.<\/span><\/p>\n

Nj\u00eb drejtim premtues k\u00ebrkimi \u00ebsht\u00eb zhvillimi i terapive t\u00eb gjera antivirale q\u00eb mund t\u00eb neutralizojn\u00eb shum\u00eb lloje virusesh, p\u00ebrfshir\u00eb ato ende t\u00eb panjohura.<\/span><\/p>\n

Sinjali i imunitetit<\/span><\/strong><\/p>\n

Interferonet e Tipit 1 jan\u00eb proteina q\u00eb prodhohen natyrsh\u00ebm n\u00eb trup si p\u00ebrgjigje ndaj infeksioneve virale. Ato paralajm\u00ebrojn\u00eb qelizat e tjera se organizmi \u00ebsht\u00eb n\u00ebn sulm dhe nxisin nj\u00eb gjendje gatishm\u00ebrie q\u00eb forcon mbrojtjen kund\u00ebr viruseve. Ky proces shkakton inflamacion, i cili mund t\u00eb ket\u00eb efekte t\u00eb pad\u00ebshiruara \u2013 nj\u00eb arsye pse interferonet nuk kan\u00eb rezultuar gjithmon\u00eb efikase si trajtim.<\/span><\/p>\n

Dy proteina t\u00eb r\u00ebnd\u00ebsishme n\u00eb k\u00ebt\u00eb rrug\u00eb biologjike jan\u00eb USP18 dhe ISG15, t\u00eb cilat mbajn\u00eb n\u00ebn kontroll p\u00ebrgjigjen inflamatore. Mungesa e tyre shkakton reaksione t\u00eb forta imune. Nd\u00ebrsa mungesa e USP18 \u00ebsht\u00eb shum\u00eb e rrezikshme, mungesa e ISG15 \u00ebsht\u00eb m\u00eb e leht\u00eb dhe \u00ebsht\u00eb identifikuar te 10 familje n\u00eb mbar\u00eb bot\u00ebn. Fibroblastet e personave pa ISG15 treguan rezistenc\u00eb t\u00eb jasht\u00ebzakonshme ndaj infeksioneve virale n\u00eb laborator.<\/span><\/p>\n

\"\"<\/p>\n

Roli i ISG15<\/span><\/strong><\/p>\n

Rreth 15 vite m\u00eb par\u00eb, imunologu Dusan Bogunovic nga Universiteti Columbia vuri re se disa pacient\u00eb me infeksione bakteriale t\u00eb p\u00ebrs\u00ebritura shfaqnin nj\u00eb reaksion tipik p\u00ebr s\u00ebmundjet virale. Ai zbuloi se atyre u mungonte ISG15. Pa k\u00ebt\u00eb protein\u00eb, rreth 60 proteina t\u00eb tjera grumbullohen brenda qelizave, duke prodhuar nj\u00eb reagim t\u00eb fort\u00eb antiviral.<\/span><\/p>\n

Megjith\u00ebse \u00e7aktivizimi i ISG15 nuk mund t\u00eb p\u00ebrdoret te pacient\u00ebt p\u00ebr shkak t\u00eb rreziqeve, studiuesit analizuan 60 proteinat dhe zgjodh\u00ebn 10 prej tyre si kandidat\u00eb p\u00ebr terapi t\u00eb re. Ata paketuan mRNA q\u00eb kodon k\u00ebto proteina brenda nanogrimcave lipidike \u2013 t\u00eb ngjashme me teknologjin\u00eb e vaksinave kund\u00ebr COVID-19 \u2013 dhe i shp\u00ebrndan\u00eb n\u00eb mushk\u00ebrit\u00eb e minjve dhe hamst\u00ebr\u00ebve p\u00ebrmes pikave t\u00eb hund\u00ebs.<\/span><\/p>\n

K\u00ebto proteina ndez\u00ebn nj\u00eb p\u00ebrgjigje t\u00eb but\u00eb inflamatore antivirale, e cila mjaftoi p\u00ebr t\u00eb frenuar replikimin e viruseve t\u00eb gripit dhe koronavirusit dhe p\u00ebr t\u00eb ulur ashp\u00ebrsin\u00eb e s\u00ebmundjes p\u00ebr 3\u20134 dit\u00eb krahasuar me grupet kontrolluese.<\/span><\/p>\n

Hapat e ardhsh\u00ebm<\/span><\/strong><\/p>\n

Studimi \u00ebsht\u00eb ende n\u00eb fazat e para dhe k\u00ebrkon teste t\u00eb gjera p\u00ebr efektivitet dhe siguri p\u00ebrpara p\u00ebrdorimit klinik. Deri tani \u00ebsht\u00eb testuar vet\u00ebm n\u00eb mushk\u00ebrit\u00eb e brejt\u00ebsve, por shum\u00eb s\u00ebmundje virale prekin edhe organe t\u00eb tjera, ndaj m\u00ebnyra e shp\u00ebrndarjes s\u00eb trajtimit do t\u00eb duhet t\u00eb p\u00ebrshtatet.<\/span><\/p>\n

Studiuesit shpresojn\u00eb se kjo qasje mund t\u00eb sh\u00ebrbej\u00eb n\u00eb t\u00eb ardhmen si nd\u00ebrhyrje e hershme gjat\u00eb shp\u00ebrthimeve t\u00eb viruseve t\u00eb njohura \u2013 si gripi dhe HIV\/SIDA \u2013 apo viruseve t\u00eb reja, si SARS-CoV-2. N\u00ebse konfirmohet, ajo mund t\u00eb b\u00ebhet nj\u00eb arm\u00eb e vlefshme p\u00ebrkrah terapive aktuale antivirale, t\u00eb cilat shpesh jan\u00eb shum\u00eb specifike dhe t\u00eb kufizuara, shkruan Ynet<\/a><\/span>.<\/span><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"

S\u00ebmundjet virale mbeten nd\u00ebr shkaqet kryesore t\u00eb s\u00ebmundshm\u00ebris\u00eb dhe vdekshm\u00ebris\u00eb n\u00eb mbar\u00eb bot\u00ebn. Pandemia e gripit t\u00eb vitit 1918 shkaktoi 20\u201350 milion\u00eb viktima vet\u00ebm n\u00eb Evrop\u00eb, dhe viruse t\u00eb tilla vazhdojn\u00eb t\u00eb d\u00ebrgojn\u00eb \u00e7do vit rreth gjysm\u00eb milioni njer\u00ebz n\u00eb spital, duke marr\u00eb dhjet\u00ebra mij\u00ebra jet\u00eb. Pandemia e COVID-19 ka shkaktuar deri n\u00eb 15 milion\u00eb […]<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":51,"featured_media":775265,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[53],"tags":[],"class_list":["post-775263","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fast-foodi"],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts\/775263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/users\/51"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/comments?post=775263"}],"version-history":[{"count":99999,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts\/775263\/revisions"}],"predecessor-version":[{"id":775267,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts\/775263\/revisions\/775267"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/media\/775265"}],"wp:attachment":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/media?parent=775263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/categories?post=775263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/tags?post=775263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}