{"id":772308,"date":"2025-11-19T20:35:37","date_gmt":"2025-11-19T19:35:37","guid":{"rendered":"https:\/\/www.hashtag.al\/?p=772308"},"modified":"2025-11-19T20:35:37","modified_gmt":"2025-11-19T19:35:37","slug":"studiuesja-izraelite-ndihmon-ne-zhvillimin-e-trajtimit-qe-ul-yndyrnat-ne-gjak-me-mbi-50","status":"publish","type":"post","link":"https:\/\/www.hashtag.al\/index.php\/2025\/11\/19\/studiuesja-izraelite-ndihmon-ne-zhvillimin-e-trajtimit-qe-ul-yndyrnat-ne-gjak-me-mbi-50\/","title":{"rendered":"Studiuesja izraelite\u00a0ndihmon n\u00eb zhvillimin e trajtimit q\u00eb ul yndyrnat n\u00eb gjak me mbi 50%","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

\"\"<\/p>\n

Nj\u00eb prov\u00eb e madhe klinike nd\u00ebrkomb\u00ebtare, e udh\u00ebhequr n\u00eb Izrael nga Dr. Hofit Cohen e Qendr\u00ebs Mjek\u00ebsore Sheba, ka\u00a0treguar efikasitetin e nj\u00eb ila\u00e7i t\u00eb ri q\u00eb ul nivelet e triglicerideve me m\u00eb shum\u00eb se 50% dhe ul ndjesh\u00ebm pankreatitin k\u00ebrc\u00ebnues p\u00ebr jet\u00ebn.<\/span><\/p>\n

Gjetjet, q\u00eb p\u00ebrfshijn\u00eb n\u00ebnt\u00eb qendra mjek\u00ebsore izraelite, u publikuan k\u00ebt\u00eb muaj n\u00eb revist\u00ebn Ne\u00eb\u00a0England Journal of Medicine dhe u prezantuan n\u00eb konferenc\u00ebn vjetore t\u00eb Shoqat\u00ebs Amerikane t\u00eb Zemr\u00ebs n\u00eb New\u00a0Orleans.<\/span><\/p>\n

Dr. Cohen, drejtoresh\u00eb e Sh\u00ebrbimit p\u00ebr Diagnoz\u00ebn dhe Trajtimin e \u00c7rregullimeve t\u00eb Lipideve n\u00eb\u00a0\u00a0Qendr\u00ebn e Lipideve Strasburger t\u00eb Sheba-s, p\u00ebrshkroi ndikimin te nj\u00eb pacient, nj\u00eb vler\u00ebsues pasurish t\u00eb paluajtshme 50-vje\u00e7ar, i cili kishte vuajtur gjasht\u00eb episode pankreatiti vitet e fundit. <\/span><\/p>\n

Pavar\u00ebsisht diet\u00ebs s\u00eb rrept\u00eb, ndryshimeve n\u00eb stilin e jet\u00ebs dhe terapis\u00eb maksimale me ila\u00e7e, ai k\u00ebrkonte shtrime t\u00eb shpeshta n\u00eb spital, p\u00ebrfshir\u00eb n\u00eb kujdesin intensiv. N\u00ebn trajtimin e studimit, tha ajo, nivelet e tij t\u00eb triglicerideve u kthyen n\u00eb normale dhe ai nuk ka pasur nevoj\u00eb p\u00ebr kujdes urgjent q\u00eb at\u00ebher\u00eb.<\/span><\/p>\n

“Ky \u00ebsht\u00eb nj\u00eb zbulim i v\u00ebrtet\u00eb,”<\/i><\/em>\u00a0tha Cohen.<\/span><\/p>\n

“Deri tani, nuk kishte asnj\u00eb trajtim efektiv p\u00ebr pacient\u00ebt me nivele jasht\u00ebzakonisht t\u00eb larta t\u00eb triglicerideve dhe pankreatit t\u00eb p\u00ebrs\u00ebritur. Studimi tregoi nj\u00eb r\u00ebnie t\u00eb ndjeshme t\u00eb triglicerideve dhe nj\u00eb <\/i><\/em>ulje t\u00eb madhe <\/i><\/em>t\u00eb rrezikut t\u00eb pankreatitit. Kjo \u00ebsht\u00eb nj\u00eb terapi q\u00eb ndryshon rrjedh\u00ebn e jet\u00ebs s\u00eb k\u00ebtyre pacient\u00ebve.”<\/i><\/em><\/span><\/p>\n

\u00c7far\u00eb jan\u00eb trigliceridet dhe pse jan\u00eb t\u00eb rrezikshme?<\/b><\/strong><\/span><\/p>\n

Trigliceridet jan\u00eb nj\u00eb lloj yndyre n\u00eb gjak, t\u00eb p\u00ebrb\u00ebra nga tre acide yndyrore t\u00eb bashkangjitura me glicerolin. Pas ngr\u00ebnies, zorra prodhon trigliceride dhe i transporton ato p\u00ebrmes qarkullimit t\u00eb gjakut n\u00ebp\u00ebrmjet grimcave t\u00eb quajtura kilomikrone. M\u00ebl\u00e7ia prodhon grimca t\u00eb ngjashme, t\u00eb njohura si VLDL. K\u00ebto grimca t\u00eb pasura me trigliceride furnizojn\u00eb energji ose ruhen n\u00eb indin dhjamor.<\/span><\/p>\n

Nivelet normale t\u00eb triglicerideve jan\u00eb n\u00ebn 150 mg\/dL. Nivelet midis 150 dhe 499 konsiderohen t\u00eb larta, 500 deri n\u00eb 999 jan\u00eb duksh\u00ebm t\u00eb larta, dhe \u00e7do gj\u00eb mbi 1,000 mg\/dL \u00ebsht\u00eb jasht\u00ebzakonisht e lart\u00eb dhe mbart nj\u00eb rrezik real t\u00eb pankreatitit si dhe t\u00eb s\u00ebmundjeve kardiovaskulare.<\/span><\/p>\n

Trigliceridet e larta rrisin rrezikun p\u00ebr ateroskleroz\u00eb, atake n\u00eb zem\u00ebr, goditje n\u00eb tru dhe s\u00ebmundje vaskulare periferike. Nivelet shum\u00eb t\u00eb larta rrisin ndjesh\u00ebm rrezikun p\u00ebr pankreatit akut, nj\u00eb gjendje ndonj\u00ebher\u00eb k\u00ebrc\u00ebnuese p\u00ebr jet\u00ebn q\u00eb mund t\u00eb k\u00ebrkoj\u00eb kujdes intensiv dhe mund t\u00eb shkaktoj\u00eb d\u00ebmtim t\u00eb p\u00ebrhersh\u00ebm.<\/span><\/p>\n

\"\"<\/p>\n

Pse rriten trigliceridet dhe pse trajtimet aktuale d\u00ebshtojn\u00eb<\/b><\/strong><\/span><\/p>\n

Cohen tha se trigliceridet e larta zakonisht vijn\u00eb si pasoj\u00eb e nj\u00eb p\u00ebrzierje faktor\u00ebsh gjenetik\u00eb dhe mjedisor\u00eb. Dietat e pasura me yndyrna dhe karbohidrate t\u00eb thjeshta, mungesa e ushtrimeve, p\u00ebrdorimi i tepruar i alkoolit, diabeti i pakontrolluar, mosfunksionimi i veshkave, hipotiroidizmi, prodhimi i tep\u00ebrt i kortizolit dhe obeziteti jan\u00eb kontribuesit kryesor\u00eb. \u00c7rregullimet e rralla gjenetike gjithashtu mund t\u00eb d\u00ebmtojn\u00eb aft\u00ebsin\u00eb e trupit p\u00ebr t\u00eb zb\u00ebrthyer trigliceridet, duke shkaktuar nivele jasht\u00ebzakonisht t\u00eb larta q\u00eb n\u00eb mosh\u00eb t\u00eb re.<\/span><\/p>\n

Trajtimi n\u00eb p\u00ebrgjith\u00ebsi fillon me ndryshime n\u00eb stilin e jet\u00ebs: diet\u00eb t\u00eb ekuilibruar,\u00a0ulje t\u00eb karbohidrateve t\u00eb thjeshta, shmangie t\u00eb alkoolit, ushtrime t\u00eb rregullta dhe kontroll t\u00eb rrept\u00eb t\u00eb diabetit. Shum\u00eb pacient\u00eb marrin gjithashtu statina p\u00ebr t\u00eb zvog\u00ebluar rrezikun e s\u00ebmundjeve t\u00eb zemr\u00ebs. Kur nivelet tejkalojn\u00eb 500 mg\/dL, mjek\u00ebt zakonisht shtojn\u00eb fibrate ose acide yndyrore omega-3 n\u00eb doz\u00eb t\u00eb lart\u00eb, t\u00eb cilat mund t\u00eb ulin trigliceridet me 30% deri n\u00eb 50%.<\/span><\/p>\n

P\u00ebr disa pacient\u00eb – ve\u00e7an\u00ebrisht ata me nivele “n\u00eb mij\u00ebra” – k\u00ebto masa nuk jan\u00eb t\u00eb mjaftueshme. Ata vazhdojn\u00eb t\u00eb vuajn\u00eb nga pankreatiti i p\u00ebrs\u00ebritur pavar\u00ebsisht\u00a0diet\u00ebs s\u00eb rrept\u00eb. N\u00eb raste t\u00eb r\u00ebnda, pacient\u00ebt i n\u00ebnshtrohen plazmaferez\u00ebs, nj\u00eb procedur\u00eb invazive p\u00ebr t\u00eb hequr mekanikisht trigliceridet nga gjaku, shpesh \u00e7do jav\u00eb.<\/span><\/p>\n

Nj\u00eb brez i ri ila\u00e7esh rishkruan peizazhin e trajtimit<\/b><\/strong><\/span><\/p>\n

N\u00eb vitet e fundit, terapit\u00eb e p\u00ebrparuara t\u00eb bazuara n\u00eb ARN kan\u00eb shnd\u00ebrruar kujdesin p\u00ebr hipertrigliceridemi t\u00eb r\u00ebnd\u00eb. K\u00ebto trajtime synojn\u00eb proteina specifike t\u00eb p\u00ebrfshira n\u00eb metabolizmin e triglicerideve. Nj\u00eb protein\u00eb ky\u00e7e, apoC-III, ngadal\u00ebson natyrsh\u00ebm zb\u00ebrthimin e triglicerideve. Shtypja e prodhimit t\u00eb saj rrit ndjesh\u00ebm aft\u00ebsin\u00eb e trupit p\u00ebr t\u00eb pastruar yndyrnat.<\/span><\/p>\n

Volanesorsen, ila\u00e7i i par\u00eb n\u00eb k\u00ebt\u00eb klas\u00eb, u miratua n\u00eb Evrop\u00eb. Ila\u00e7i m\u00eb i ri, Olezarsen, vepron p\u00ebrmes t\u00eb nj\u00ebjtit mekaniz\u00ebm, por \u00ebsht\u00eb i synuar p\u00ebr m\u00ebl\u00e7in\u00eb dhe konsiderohet m\u00eb i sigurt. FDA e miratoi at\u00eb n\u00eb vitin 2024 p\u00ebr nj\u00eb s\u00ebmundje t\u00eb rrall\u00eb gjenetike t\u00eb quajtur sindroma familjare e kilomikronemis\u00eb (FCS), dhe pritet t\u00eb arrij\u00eb s\u00eb shpejti n\u00eb Izrael.<\/span><\/p>\n

Studimet CORE shqyrtuan n\u00ebse Olezarsen mund t\u00eb ndihmonte t\u00eb rriturit me hipertrigliceridemi t\u00eb r\u00ebnd\u00eb q\u00eb nuk kishin arritur t\u00eb arrinin nivele t\u00eb sigurta pavar\u00ebsisht ndryshimeve n\u00eb stilin e jet\u00ebs dhe trajtimeve konvencionale.<\/span><\/p>\n

\\\"\"<\/p>\n

M\u00eb shum\u00eb se 1,000 pjes\u00ebmarr\u00ebs<\/b><\/strong>\u00a0n\u00eb prov\u00eb<\/b><\/strong>dhe rezultate<\/b><\/strong>\u00a0t\u00eb jasht\u00ebzakonshme<\/b><\/strong><\/span><\/p>\n

Dy studimet e m\u00ebdha, t\u00eb dyfishta, t\u00eb kontrolluara me placebo p\u00ebrfshin\u00eb 1,061 pjes\u00ebmarr\u00ebs n\u00eb 23 vende dhe af\u00ebrsisht 140 qendra mjek\u00ebsore, p\u00ebrfshir\u00eb n\u00ebnt\u00eb n\u00eb Izrael. Pjes\u00ebmarr\u00ebsit mor\u00ebn injeksione mujore t\u00eb Olezarsen ose placebo p\u00ebr nj\u00eb vit. Studiuesit mat\u00ebn ndryshimet n\u00eb nivelet e triglicerideve dhe incidenc\u00ebn e pankreatitit.<\/span><\/p>\n

Rezultatet ishin t\u00eb habitshme: nivelet mesatare t\u00eb triglicerideve ran\u00eb nga rreth 800 mg\/dL n\u00eb ulje prej 50% deri n\u00eb 70%, var\u00ebsisht nga doza. Tet\u00ebdhjet\u00eb e pes\u00eb p\u00ebrqind e pacient\u00ebve arrit\u00ebn nivele n\u00ebn 500 mg\/dL, dhe shkalla e pankreatitit ra me m\u00eb shum\u00eb se 80%.<\/span><\/p>\n

Ila\u00e7i dukej i sigurt n\u00eb p\u00ebrgjith\u00ebsi, me shkall\u00eb t\u00eb ngjashme t\u00eb efekteve an\u00ebsore dhe nd\u00ebrprerjes s\u00eb trajtimit krahasuar me placebon. Megjithat\u00eb, studiuesit vun\u00eb re disa gjetje q\u00eb k\u00ebrkonin mbik\u00ebqyrje: rritje t\u00eb lehta t\u00eb enzimave t\u00eb m\u00ebl\u00e7is\u00eb, ulje t\u00eb\u00a0trombociteve tek disa pacient\u00eb – m\u00eb t\u00eb zakonshme n\u00eb doza m\u00eb t\u00eb larta – dhe rritje t\u00eb varura nga doza e yndyr\u00ebs n\u00eb m\u00ebl\u00e7i. Ndjekja afatgjat\u00eb \u00ebsht\u00eb duke vazhduar.<\/span><\/p>\n

Nj\u00eb ‘ndryshues i loj\u00ebs’ p\u00ebr pacient\u00ebt<\/b><\/strong><\/span><\/p>\n

Cohen tha se deri tani, pacient\u00ebt me nivele t\u00eb skajshme t\u00eb triglicerideve shpesh nuk kishin alternativa efektive p\u00ebrve\u00e7 procedurave t\u00eb vijueshme invazive. Olezarsen, tha ajo, ofron nj\u00eb mund\u00ebsi q\u00eb ndryshon jet\u00ebn q\u00eb ul ndjesh\u00ebm trigliceridet, ul episodet e pankreatitit dhe mund t\u00eb eliminoj\u00eb nevoj\u00ebn p\u00ebr plazmaferez\u00eb, shkruan Ynet<\/a><\/span>.<\/span><\/p>\n

“Ky \u00ebsht\u00eb nj\u00eb trajtim q\u00eb ndryshon jet\u00ebn e k\u00ebtyre pacient\u00ebve,”<\/i><\/em>\u00a0tha ajo, duke e quajtur at\u00eb nj\u00eb p\u00ebrparim t\u00eb v\u00ebrtet\u00eb dhe nj\u00eb “ndryshues t\u00eb loj\u00ebs” n\u00eb kujdesin p\u00ebr hipertrigliceridemin\u00eb e r\u00ebnd\u00eb. Kombinimi i ila\u00e7it t\u00eb ri me zakonet e jetes\u00ebs s\u00eb sh\u00ebndetshme, kontrollin e diabetit dhe terapit\u00eb ekzistuese mund t\u00eb zvog\u00ebloj\u00eb ndjesh\u00ebm s\u00ebmundjen dhe vdekjen tek pacient\u00ebt me nivele t\u00eb rrezikshme, shtoi ajo.<\/span><\/p>\n

Dr. Dov Gavish, kryetar i Shoqat\u00ebs s\u00eb Ateroskleroz\u00ebs n\u00eb Izrael dhe nj\u00eb mjek i lart\u00eb n\u00eb Qendr\u00ebn Mjek\u00ebsore Shaare Zedek, tha se ila\u00e7et m\u00eb t\u00eb reja t\u00eb disponueshme p\u00ebrmes provave klinike tashm\u00eb i ndihmojn\u00eb pacient\u00ebt t\u00eb mbajn\u00eb nivele shum\u00eb m\u00eb t\u00eb ul\u00ebta t\u00eb triglicerideve, t\u00eb zvog\u00eblojn\u00eb episodet e pankreatitit dhe t\u00eb p\u00ebrmir\u00ebsojn\u00eb kontrollin e diabetit. M\u00eb shum\u00eb trajtime jan\u00eb n\u00eb zhvillim dhe “do na lejojn\u00eb t\u00eb ofrojm\u00eb kujdes edhe m\u00eb t\u00eb gjer\u00eb dhe t\u00eb parandalojm\u00eb komplikime t\u00eb r\u00ebnda”, tha ai.<\/span><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"

Nj\u00eb prov\u00eb e madhe klinike nd\u00ebrkomb\u00ebtare, e udh\u00ebhequr n\u00eb Izrael nga Dr. Hofit Cohen e Qendr\u00ebs Mjek\u00ebsore Sheba, ka\u00a0treguar efikasitetin e nj\u00eb ila\u00e7i t\u00eb ri q\u00eb ul nivelet e triglicerideve me m\u00eb shum\u00eb se 50% dhe ul ndjesh\u00ebm pankreatitin k\u00ebrc\u00ebnues p\u00ebr jet\u00ebn. Gjetjet, q\u00eb p\u00ebrfshijn\u00eb n\u00ebnt\u00eb qendra mjek\u00ebsore izraelite, u publikuan k\u00ebt\u00eb muaj n\u00eb revist\u00ebn […]<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":51,"featured_media":772309,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[53],"tags":[],"class_list":["post-772308","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fast-foodi"],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts\/772308","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/users\/51"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/comments?post=772308"}],"version-history":[{"count":99999,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts\/772308\/revisions"}],"predecessor-version":[{"id":772312,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts\/772308\/revisions\/772312"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/media\/772309"}],"wp:attachment":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/media?parent=772308"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/categories?post=772308"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/tags?post=772308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}