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Frenuesit e pomp\u00ebs protonike (PPI), nj\u00eb klas\u00eb popullore e barnave p\u00ebr urthin, jan\u00eb t\u00eb lidhur me kancerin e stomakut, zbuloi nj\u00eb rishikim i koh\u00ebve t\u00eb fundit.<\/span><\/p>\n Rishikimi tregon se p\u00ebrdorimi i zgjatur i PPI-ve – q\u00eb tejkalon tre muaj – “\u00ebsht\u00eb i lidhur ndjesh\u00ebm me nj\u00eb rrezik t\u00eb rritur t\u00eb kancerit”, nd\u00ebrsa p\u00ebrdorimi afatshkurt\u00ebr “duket se paraqet nj\u00eb rrezik relativisht m\u00eb t\u00eb ul\u00ebt”, shkruan autor\u00ebt.<\/span><\/p>\n PPI-t\u00eb jan\u00eb barna t\u00eb fuqishme q\u00eb ulin aciditetin e stomakut. Ato funksionojn\u00eb duke u lidhur n\u00eb m\u00ebnyr\u00eb t\u00eb pakthyeshme me pompat e protonit – proteinat n\u00eb stomak q\u00eb l\u00ebshojn\u00eb protone, nj\u00eb p\u00ebrb\u00ebr\u00ebs i acidit t\u00eb stomakut. Ky veprim parandalon sekretimin e protoneve.<\/span><\/p>\n PPI-t\u00eb zakonisht p\u00ebrshkruhen p\u00ebr t\u00eb trajtuar refluksin e acidit, q\u00eb ndodh kur acidi n\u00eb stomak e kthen lart ezofagun, duke shkaktuar urth. Ato p\u00ebrdoren gjithashtu p\u00ebr t\u00eb trajtuar s\u00ebmundjen e refluksit gastroezofageal (GERD), nj\u00eb form\u00eb m\u00eb kronike e refluksit acid, si dhe ulcerat gastrike dhe t\u00eb zorr\u00ebve.<\/span><\/p>\n Shembuj t\u00eb PPI-ve p\u00ebrfshijn\u00eb barna pa recet\u00eb si omeprazoli (Prilosec), esomeprazoli (Nexium) dhe lansoprazoli (Prevacid). Disa PPI k\u00ebrkojn\u00eb receta, t\u00eb tilla si rabeprazole (Aciphex), pantoprazole (Protonix) dhe dexlansoprazole (Dexilant).<\/span><\/p>\n Rritja e rrezikut t\u00eb kancerit t\u00eb stomakut dhe polipeve<\/strong><\/span><\/p>\n Autor\u00ebt shqyrtuan disa punime q\u00eb hetonin lidhjen midis p\u00ebrdorimit t\u00eb PPI dhe rrezikut t\u00eb kancerit, duke gjetur nj\u00eb lidhje midis p\u00ebrdorimit t\u00eb PPI dhe kancerit t\u00eb stomakut dhe polipeve. Nuk u identifikuan lidhje t\u00eb tjera me kancerin.<\/span><\/p>\n Nj\u00eb nga studimet q\u00eb ata cituan vler\u00ebsoi t\u00eb dh\u00ebnat nga rreth 2400 regjistrime dhe zbuloi se p\u00ebrdorimi afatgjat\u00eb p\u00ebr nj\u00eb vit dhe tre vjet u shoq\u00ebrua me nj\u00eb rritje 1.5 dhe 2.4 her\u00eb n\u00eb rrezikun e kancerit t\u00eb stomakut, p\u00ebrkat\u00ebsisht.<\/span><\/p>\n Hulumtime t\u00eb tjera q\u00eb ndoq\u00ebn 3271 pacient\u00eb t\u00eb cil\u00ebve iu dhan\u00eb PPI pas nj\u00eb infeksioni me Helicobacter pylori zbuluan se p\u00ebrdorimi afatgjat\u00eb i PPI ishte i lidhur me nj\u00eb rritje t\u00eb dyfisht\u00eb t\u00eb rrezikut t\u00eb kancerit t\u00eb stomakut.<\/span><\/p>\n Nd\u00ebrsa nj\u00eb studim te femrat zbuloi se p\u00ebrdorimi i PPI-s\u00eb lidhej me rrezikun e pak\u00ebsuar t\u00eb kancerit t\u00eb gjirit, vezoreve dhe qaf\u00ebs s\u00eb mitr\u00ebs, autor\u00ebt e rishikimit paralajm\u00ebruan kund\u00ebr p\u00ebrdorimit t\u00eb nj\u00ebkohsh\u00ebm t\u00eb PPI-ve n\u00eb trajtimin e kancerit, duke p\u00ebrmendur studime q\u00eb gjet\u00ebn rezultate m\u00eb t\u00eb k\u00ebqija dhe rritje t\u00eb rrezikut t\u00eb vdekshm\u00ebris\u00eb.<\/span><\/p>\n Pse ky rrezik?<\/strong><\/span><\/p>\n Disa mekanizma t\u00eb mundsh\u00ebm mund t\u00eb shpjegojn\u00eb se si PPI-t\u00eb mund t\u00eb kontribuojn\u00eb n\u00eb zhvillimin e kancerit. K\u00ebto barna mund t\u00eb prishin sh\u00ebndetin e mikrobiom\u00ebs s\u00eb zorr\u00ebve duke rritur pH-n\u00eb e p\u00ebrmbajtjes s\u00eb stomakut. Kjo \u201cmund t\u00eb ndryshoj\u00eb potencialisht mikrobiom\u00ebn e zorr\u00ebve, t\u00eb zvog\u00ebloj\u00eb shum\u00ebllojshm\u00ebrin\u00eb dhe boll\u00ebkun e baktereve t\u00eb dobishme dhe t\u00eb \u00e7oj\u00eb n\u00eb inflamacion gastrointestinal. Nga ana tjet\u00ebr, kjo mund t\u00eb nxis\u00eb rritjen e tep\u00ebrt t\u00eb baktereve t\u00eb d\u00ebmshme q\u00eb prodhojn\u00eb kancerogjen\u00eb dhe rrisin rrezikun e kancerit\u201d<\/em>, shkruan autor\u00ebt.<\/span><\/p>\n PPI-t\u00eb mund t\u00eb rezultojn\u00eb gjithashtu n\u00eb hipergastrinemi. Meqen\u00ebse ato rrisin pH t\u00eb stomakut, stomaku mund t\u00eb rris\u00eb prodhimin e gastrin\u00ebs, nj\u00eb lloj proteine \u200b\u200bn\u00eb stomak.<\/span><\/p>\n Megjithat\u00eb, gastrina stimulon rritjen dhe veprimtarin\u00eb e qelizave t\u00eb caktuara t\u00eb stomakut, dhe sa m\u00eb i lart\u00eb t\u00eb jet\u00eb p\u00ebrqendrimi i gastrin\u00ebs, aq m\u00eb i madh \u00ebsht\u00eb veprimtaria dhe p\u00ebrhapja e qelizave, duke rritur rrezikun e kancerit.<\/span><\/p>\n P\u00ebrve\u00e7 k\u00ebtyre mekanizmave t\u00eb propozuar, PPI-t\u00eb kan\u00eb gjithashtu nj\u00eb gam\u00eb t\u00eb gjer\u00eb efektesh an\u00ebsore. Rritja e pH e acidit t\u00eb stomakut mund t\u00eb \u00e7oj\u00eb n\u00eb dispepsi, mang\u00ebsi ushqyese, rritje t\u00eb tep\u00ebrt t\u00eb baktereve dhe probleme t\u00eb zorr\u00ebve. Ajo \u00ebsht\u00eb gjithashtu e lidhur me infeksionet me baktere si Helicobacter pylori dhe Clostridium difficile.<\/span><\/p>\n Infeksionet e Helicobacter pylori mund t\u00eb shkaktojn\u00eb ul\u00e7era t\u00eb dhimbshme n\u00eb stomak. Bakteret mbijetojn\u00eb dhe shumohen n\u00eb nj\u00eb pH midis 3.5 dhe 8. Nj\u00eb stomak i sh\u00ebndetsh\u00ebm ka nj\u00eb pH midis 1 dhe 2.<\/span><\/p>\n Infeksionet e Clostridium difficile zakonisht transmetohen p\u00ebrmes ushqimit. Megjithat\u00eb, rreziku i infeksioneve mund t\u00eb rritet n\u00ebse acidi i stomakut nuk \u00ebsht\u00eb mjaftuesh\u00ebm acid p\u00ebr t\u00eb vrar\u00eb bakteret.<\/span><\/p>\n Sipas rishikimit, p\u00ebrdorimi i PPI shoq\u00ebrohet gjithashtu me nj\u00eb rrezik n\u00eb rritje t\u00eb demenc\u00ebs, frakturave, osteoporoz\u00ebs dhe s\u00ebmundjeve t\u00eb m\u00ebl\u00e7is\u00eb dhe veshkave.<\/span><\/p>\n Alternativat p\u00ebr frenuesit e pomp\u00ebs protonike<\/strong><\/span><\/p>\n Njer\u00ebzit me GERD dhe dispepsi mund t\u00eb z\u00ebvend\u00ebsojn\u00eb PPI-t\u00eb me alternativa m\u00eb pak t\u00eb fuqishme, duke p\u00ebrfshir\u00eb antacidet dhe bllokuesit H2, pasi problemet e tyre themelore fiziologjike t\u00eb menaxhohen m\u00eb mir\u00eb.<\/span><\/p>\n Dr. Scott Rollins nga Qendra e Mjek\u00ebsis\u00eb Integruese t\u00eb Kolorados Per\u00ebndimore tha p\u00ebr The Epoch Times se nd\u00ebrsa PPI-t\u00eb mund t\u00eb jen\u00eb shum\u00eb efektive n\u00eb kontrollin e nj\u00eb ul\u00e7ere potencialisht t\u00eb rrezikshme t\u00eb stomakut tek k\u00ebta pacient\u00eb, ato mund t\u00eb ken\u00eb efekte t\u00eb kund\u00ebrta kumulative.<\/span><\/p>\n Krahasuar me antacidet dhe bllokuesit H2, t\u00eb p\u00ebrdorura tradicionalisht p\u00ebr t\u00eb leht\u00ebsuar urthin, PPI-t\u00eb aktivizohen m\u00eb ngadal\u00eb dhe zgjasin shum\u00eb m\u00eb gjat\u00eb.<\/span><\/p>\n Antacidet rrisin pH e acidit t\u00eb stomakut menj\u00ebher\u00eb pas hyrjes n\u00eb stomak dhe zgjasin vet\u00ebm p\u00ebr rreth nj\u00eb or\u00eb. Bllokuesit H2 zgjasin disa or\u00eb, por PPI-t\u00eb mund t\u00eb zgjasin deri n\u00eb 12 or\u00eb p\u00ebr t’u aktivizuar dhe efektet e tyre mund t\u00eb zgjasin deri n\u00eb tre dit\u00eb.<\/span><\/p>\n Pacient\u00ebt gjithashtu shpesh k\u00ebshillohen t\u00eb marrin PPI \u00e7do dit\u00eb, dhe shum\u00eb i marrin ato p\u00ebr vite me rradh\u00eb. Kjo mund t\u00eb shkaktoj\u00eb probleme afatgjata, duke p\u00ebrfshir\u00eb problemet inflamatore t\u00eb zorr\u00ebve.<\/span><\/p>\n Dr. Rollins ka zbuluar se shum\u00eb pacient\u00eb q\u00eb ankohen p\u00ebr GERD shpesh kan\u00eb probleme inflamatore t\u00eb zorr\u00ebve t\u00eb pazgjidhura. Pasi k\u00ebto probleme t\u00eb adresohen duke p\u00ebrmir\u00ebsuar diet\u00ebn p\u00ebr 6 deri n\u00eb 12 jav\u00eb, simptomat e GERD priren t\u00eb zgjidhen ose p\u00ebrmir\u00ebsohen ndjesh\u00ebm, k\u00ebshtu q\u00eb pacient\u00ebt duhet t\u00eb marrin vet\u00ebm antacidet.<\/span><\/p>\n Ai gjithashtu vuri n\u00eb dukje se nd\u00ebrsa urthi shpesh trajtohet duke reduktuar acidin e stomakut, n\u00eb m\u00ebnyr\u00eb kund\u00ebrintuitive, mund t\u00eb ndodh\u00eb p\u00ebr shkak t\u00eb acidit t\u00eb pamjaftuesh\u00ebm t\u00eb stomakut, i cili mund t\u00eb ndodh\u00eb p\u00ebr shkak t\u00eb mosh\u00ebs s\u00eb vjet\u00ebr, problemeve t\u00eb tiroides dhe nj\u00eb lloj s\u00ebmundje autoimune t\u00eb stomakut.<\/span><\/p>\n Dr. Jonathan Wright, i specializuar n\u00eb terapit\u00eb natyrale, tha n\u00eb nj\u00eb video n\u00eb YouTube se “99 p\u00ebr qind” e pacient\u00ebve t\u00eb tij q\u00eb p\u00ebrjetojn\u00eb urth vuajn\u00eb nga acidi i pamjaftuesh\u00ebm n\u00eb stomak dhe jo nga teprica.<\/span><\/p>\n Midis ezofagut dhe stomakut ndodhet nj\u00eb unaz\u00eb muskulore e njohur si sfinkteri i posht\u00ebm. Ky muskul unazor \u00ebsht\u00eb hapja e stomakut dhe \u00ebsht\u00eb p\u00ebrgjegj\u00ebs p\u00ebr mbylljen e tij p\u00ebr t\u00eb parandaluar q\u00eb ushqimi i patretur dhe acidi i stomakut t\u00eb kthehen n\u00eb ezofag.<\/span><\/p>\n Urthi ndodh kur sfinkteri nuk mbyllet si\u00e7 duhet. Acidi dhe ushqimi kthehen n\u00eb ezofag, duke shkaktuar dhimbje dhe d\u00ebmtime.<\/span><\/p>\n Disa gj\u00ebra mund t\u00eb shkaktojn\u00eb mosfunksionim t\u00eb sfinkterit. Nj\u00ebra \u00ebsht\u00eb se pH e acidit t\u00eb stomakut nuk \u00ebsht\u00eb mjaftuesh\u00ebm i ul\u00ebt. Prandaj, nd\u00ebrsa PPI-t\u00eb mund t\u00eb zvog\u00eblojn\u00eb simptomat, ato n\u00eb fakt mund t\u00eb jen\u00eb kund\u00ebrproduktive.<\/span><\/p>\n Prandaj, Dr. Wright rekomandon q\u00eb pacient\u00ebt, urthi i t\u00eb cil\u00ebve shkaktohet nga acidi i pamjaftuesh\u00ebm i stomakut, mund t\u00eb plot\u00ebsojn\u00eb me acid klorhidrik betain\u00eb (acid stomaku) pasi t\u00eb fillojn\u00eb nj\u00eb vakt.<\/span><\/p>\n Faktor\u00eb t\u00eb tjer\u00eb q\u00eb mund t\u00eb ndikojn\u00eb n\u00eb sfinkterin p\u00ebrfshijn\u00eb alkoolin, kafein\u00ebn dhe duhanin. T\u00eb qenit mbipesh\u00eb gjithashtu mund t\u00eb ushtroj\u00eb m\u00eb shum\u00eb presion n\u00eb stomak, duke \u00e7uar n\u00eb refluks acidi.<\/span><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":" Frenuesit e pomp\u00ebs protonike (PPI), nj\u00eb klas\u00eb popullore e barnave p\u00ebr urthin, jan\u00eb t\u00eb lidhur me kancerin e stomakut, zbuloi nj\u00eb rishikim i koh\u00ebve t\u00eb fundit. Rishikimi tregon se p\u00ebrdorimi i zgjatur i PPI-ve – q\u00eb tejkalon tre muaj – “\u00ebsht\u00eb i lidhur ndjesh\u00ebm me nj\u00eb rrezik t\u00eb rritur t\u00eb kancerit”, nd\u00ebrsa p\u00ebrdorimi afatshkurt\u00ebr “duket […]<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":51,"featured_media":667251,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[53],"tags":[],"class_list":["post-667249","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fast-foodi"],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts\/667249","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/users\/51"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/comments?post=667249"}],"version-history":[{"count":0,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts\/667249\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/media\/667251"}],"wp:attachment":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/media?parent=667249"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/categories?post=667249"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/tags?post=667249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}