{"id":528591,"date":"2022-06-08T10:58:25","date_gmt":"2022-06-08T08:58:25","guid":{"rendered":"https:\/\/www.hashtag.al\/?p=528591"},"modified":"2022-06-08T10:58:25","modified_gmt":"2022-06-08T08:58:25","slug":"studimi-mahnites-ne-shba-mjekimi-eksperimental-sheron-te-semuret-me-kancer","status":"publish","type":"post","link":"https:\/\/www.hashtag.al\/index.php\/2022\/06\/08\/studimi-mahnites-ne-shba-mjekimi-eksperimental-sheron-te-semuret-me-kancer\/","title":{"rendered":"Studimi mahnit\u00ebs n\u00eb SHBA, mjekimi eksperimental sh\u00ebron t\u00eb s\u00ebmur\u00ebt me kancer","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

\"\"<\/span><\/p>\n

M\u00eb shum\u00eb se nj\u00eb duzin\u00eb pacient\u00ebsh me kancer rektal n\u00eb Shtetet e Bashkuara e kan\u00eb par\u00eb kancerin e tyre t\u00eb zhduket pasi iu n\u00ebnshtruan imunoterapis\u00eb eksperimentale, n\u00eb at\u00eb q\u00eb mjek\u00ebt e quajn\u00eb nj\u00eb rezultat mahnit\u00ebs.<\/span><\/p>\n

Pacient\u00ebt, t\u00eb cil\u00ebt ishin pjes\u00eb e nj\u00eb sprove t\u00eb vog\u00ebl klinike t\u00eb udh\u00ebhequr nga studiues nga Qendra e Kancerit Memorial Sloan Kettering (MSK) n\u00eb Nju Jork, pan\u00eb q\u00eb tumoret e tyre t\u00eb zhdukeshin pasi u trajtuan me nj\u00eb ila\u00e7 eksperimental t\u00eb quajtur dotarlimab.<\/span><\/p>\n

holl\u00ebsit\u00eb e prov\u00ebs u publikuan t\u00eb diel\u00ebn n\u00eb Ne\u00eb England Journal of Medicine. Punimi p\u00ebrshkruan rezultatet e 12 pacient\u00ebve me kancer rektal, t\u00eb cil\u00ebt pan\u00eb q\u00eb kanceri i tyre u zhduk pas trajtimit me dotarlimab.<\/span><\/p>\n

Pjes\u00ebmarr\u00ebsit mor\u00ebn nj\u00eb doz\u00eb dotarlimab \u00e7do tre jav\u00eb p\u00ebr gjasht\u00eb muaj, me iden\u00eb se do t’u duhej t’i n\u00ebnshtroheshin trajtimeve standarde t\u00eb kimioterapis\u00eb, terapis\u00eb me rrezatim dhe kirurgjis\u00eb pas trajtimit.<\/span><\/p>\n

Megjithat\u00eb, studiuesit zbuluan se n\u00eb \u00e7do rast, kanceri u pastrua vet\u00ebm p\u00ebrmes trajtimit eksperimental.<\/span><\/p>\n

Prova \u00ebsht\u00eb p\u00ebrsh\u00ebndetur si i para n\u00eb trajtimin e kancerit, me nj\u00eb nga autor\u00ebt e gazet\u00ebs, Dr Luis Diaz Jr i Memorial Sloan Kettering, duke i th\u00ebn\u00eb Ne\u00eb York Times se ai nuk dinte p\u00ebr asnj\u00eb studim tjet\u00ebr n\u00eb t\u00eb cilin nj\u00eb trajtim zhdukte plot\u00ebsisht nj\u00eb kancer n\u00eb \u00e7do pacientit.<\/span><\/p>\n

“Un\u00eb besoj se kjo \u00ebsht\u00eb hera e par\u00eb q\u00eb ndodh n\u00eb historin\u00eb e kancerit.”<\/em> – tha ai.<\/span><\/p>\n

Imunoterapia shfryt\u00ebzon sistemin imunitar t\u00eb trupit p\u00ebr t\u00eb identifikuar dhe shkat\u00ebrruar qelizat e kancerit.<\/span><\/p>\n

Testi u p\u00ebrqendrua n\u00eb nj\u00eb n\u00ebngrup t\u00eb pacient\u00ebve me kancer rektal, kanceri i t\u00eb cil\u00ebve kishte nj\u00eb mutacion specifik, tha MSK n\u00eb nj\u00eb deklarat\u00eb.<\/span><\/p>\n

Ky lloj kanceri rektal, i njohur si kanceri rektal me munges\u00eb t\u00eb riparimit t\u00eb mosp\u00ebrputhjes (MMRd), priret t’i p\u00ebrgjigjet dob\u00ebt regjimeve standarde t\u00eb kimioterapis\u00eb. N\u00eb prov\u00eb, studiuesit donin t\u00eb hetonin n\u00ebse vet\u00ebm imunoterapia mund t\u00eb mundte kancerin rektal q\u00eb nuk ishte p\u00ebrhapur n\u00eb inde t\u00eb tjera, tha organizata.<\/span><\/p>\n

Hulumtimi, i cili \u00ebsht\u00eb n\u00eb vazhdim, ka par\u00eb t\u00eb pakt\u00ebn 14 pacient\u00eb t\u00eb cil\u00ebve u \u00ebsht\u00eb zhdukur plot\u00ebsisht kanceri dhe asnj\u00ebri prej tyre nuk ka p\u00ebrjetuar efekte an\u00ebsore t\u00eb r\u00ebnd\u00ebsishme, shtoi ai.<\/span><\/p>\n

Nuk kishte nevoj\u00eb p\u00ebr trajtime standarde t\u00eb rrezatimit, kirurgjis\u00eb ose kimioterapis\u00eb dhe kanceri nuk \u00ebsht\u00eb kthyer n\u00eb asnj\u00eb nga pacient\u00ebt, t\u00eb cil\u00ebt kan\u00eb qen\u00eb pa kancer p\u00ebr deri n\u00eb dy vjet, tha ai.<\/span><\/p>\n

Si funksionon kjo imunoterapi?<\/span><\/strong><\/p>\n

Frym\u00ebzimi p\u00ebr studimin erdhi nga nj\u00eb test i m\u00ebparsh\u00ebm i udh\u00ebhequr nga Dr Diaz, i cili pa pacient\u00eb q\u00eb merrnin nj\u00eb ila\u00e7 t\u00eb quajtur pembrolizumab, raportoi Ne\u00eb York Times. Prova, e cila p\u00ebrfshiu pacient\u00eb me kancer t\u00eb p\u00ebrparuar q\u00eb i rezistuan trajtimit standard, pa tumoret e pjes\u00ebmarr\u00ebsve t\u00eb stabilizoheshin, tkureshin dhe madje zhdukeshin.<\/span><\/p>\n

N\u00eb prov\u00ebn e tanishme, studiuesit donin t\u00eb shihnin se \u00e7far\u00eb do t\u00eb b\u00ebnte nj\u00eb ila\u00e7 i ngjash\u00ebm, dotarlimab, n\u00ebse do t\u00eb p\u00ebrdorej p\u00ebrpara se qelizat e kancerit t\u00eb kishin nj\u00eb shans p\u00ebr t’u p\u00ebrhapur.<\/span><\/p>\n

Ky lloj trajtimi p\u00ebrqendrohet n\u00eb proteina t\u00eb ve\u00e7anta t\u00eb quajtura pika kontrolli, t\u00eb cilat b\u00ebhen nga disa lloje qelizash t\u00eb sistemit imunitar si dhe disa qeliza kanceroze, sipas Institutit Komb\u00ebtar t\u00eb Kancerit t\u00eb SHBA. Pikat e kontrollit, t\u00eb cilat i mbajn\u00eb p\u00ebrgjigjet imune t\u00eb jen\u00eb shum\u00eb t\u00eb forta, ndonj\u00ebher\u00eb mund t\u00eb parandalojn\u00eb qelizat imune t\u00eb vrasin n\u00eb m\u00ebnyr\u00eb efektive qelizat e kancerit.<\/span><\/p>\n

Ashtu si pembrolizumab, dotarlimab \u00ebsht\u00eb nj\u00eb \u2018frenues i pik\u00ebs s\u00eb kontrollit\u2019. N\u00eb thelb \u2018l\u00ebshon frenat\u2019 n\u00eb nj\u00eb qeliz\u00eb imune, duke e liruar at\u00eb t\u00eb njoh\u00eb dhe sulmoj\u00eb qelizat e kancerit, sipas MSK.<\/span><\/p>\n

\u201cKur frenat hiqen nga qelizat imune, qelizat MMRd duken ve\u00e7an\u00ebrisht t\u00eb \u00e7uditshme sepse kan\u00eb kaq shum\u00eb mutacione. K\u00ebshtu qelizat imune sulmojn\u00eb me shum\u00eb m\u00eb tep\u00ebr forc\u00eb.\u201d<\/em> – tha Dr Cercek.<\/span><\/p>\n

Nevojiten m\u00eb shum\u00eb k\u00ebrkime<\/strong><\/span><\/p>\n

Rezultatet kan\u00eb dh\u00ebn\u00eb \u2018\u00e7far\u00eb mund t\u00eb jet\u00eb nj\u00eb paraqitje e hershme e nj\u00eb ndryshimi revolucionar t\u00eb trajtimit\u2019, shkroi Dr Hanna Sanoff, nj\u00eb onkologe n\u00eb Qendr\u00ebn Gjith\u00ebp\u00ebrfshir\u00ebse t\u00eb Kancerit Lineberger n\u00eb Universitetin e Karolin\u00ebs s\u00eb Veriut, e cila nuk ishte e p\u00ebrfshir\u00eb n\u00eb test.<\/span><\/p>\n

Megjithat\u00eb, ajo shtoi se megjith\u00ebse rezultatet jan\u00eb \u2018shkak p\u00ebr optimiz\u00ebm t\u00eb madh\u2019, nj\u00eb qasje e till\u00eb “ende nuk mund t\u00eb z\u00ebvend\u00ebsoj\u00eb qasjen ton\u00eb t\u00eb tanishme t\u00eb trajtimit.<\/span><\/p>\n

\u201cNuk dihet n\u00ebse rezultatet e k\u00ebtij studimi t\u00eb vog\u00ebl t\u00eb kryer n\u00eb Qendr\u00ebn e Kancerit Memorial Sloan Kettering do t\u00eb jen\u00eb t\u00eb p\u00ebrgjith\u00ebsueshme p\u00ebr nj\u00eb popullat\u00eb m\u00eb t\u00eb gjer\u00eb pacient\u00ebsh me kancer rektal.\u201d<\/em> – tha ajo.<\/span><\/p>\n

\u201cP\u00ebr t\u00eb ofruar m\u00eb shum\u00eb informacion n\u00eb lidhje me cil\u00ebt pacient\u00eb mund t\u00eb p\u00ebrfitojn\u00eb nga imunoterapia, provat pasuese duhet t\u00eb synojn\u00eb heterogjenitetin n\u00eb mosh\u00eb, kushtet bashk\u00ebekzistuese dhe mas\u00ebn e tumorit.\u201d<\/em> – shtoi ajo.<\/span><\/p>\n

Prova klinike po vazhdon t\u00eb regjistroj\u00eb pacient\u00eb dhe po rritet, than\u00eb studiuesit e MSK. Ata po hetojn\u00eb gjithashtu p\u00ebr t\u00eb par\u00eb n\u00ebse e nj\u00ebjta metod\u00eb mund t\u00eb mposht\u00eb kanceret e tjera dhe po shikojn\u00eb pacient\u00ebt me kancer t\u00eb stomakut (stomak), prostat\u00ebs dhe pankreasit.<\/span><\/p>\n

P\u00ebrgaiti p\u00ebr Hashtag.al,<\/span> Klodian Manjani<\/span><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"

M\u00eb shum\u00eb se nj\u00eb duzin\u00eb pacient\u00ebsh me kancer rektal n\u00eb Shtetet e Bashkuara e kan\u00eb par\u00eb kancerin e tyre t\u00eb zhduket pasi iu n\u00ebnshtruan imunoterapis\u00eb eksperimentale, n\u00eb at\u00eb q\u00eb mjek\u00ebt e quajn\u00eb nj\u00eb rezultat mahnit\u00ebs. Pacient\u00ebt, t\u00eb cil\u00ebt ishin pjes\u00eb e nj\u00eb sprove t\u00eb vog\u00ebl klinike t\u00eb udh\u00ebhequr nga studiues nga Qendra e Kancerit Memorial […]<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":51,"featured_media":528592,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,53],"tags":[],"class_list":["post-528591","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ballina","category-fast-foodi"],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts\/528591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/users\/51"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/comments?post=528591"}],"version-history":[{"count":0,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts\/528591\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/media\/528592"}],"wp:attachment":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/media?parent=528591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/categories?post=528591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/tags?post=528591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}