{"id":416087,"date":"2020-12-06T22:05:31","date_gmt":"2020-12-06T21:05:31","guid":{"rendered":"https:\/\/hashtag.al\/?p=416087"},"modified":"2020-12-06T22:07:22","modified_gmt":"2020-12-06T21:07:22","slug":"shkencetaret-identifikojne-gjenin-pergjegjes-per-plakjen-hap-thelbesor-per-mjekesine-rigjeneruese","status":"publish","type":"post","link":"https:\/\/www.hashtag.al\/index.php\/2020\/12\/06\/shkencetaret-identifikojne-gjenin-pergjegjes-per-plakjen-hap-thelbesor-per-mjekesine-rigjeneruese\/","title":{"rendered":"Shkenc\u00ebtar\u00ebt identifikojn\u00eb gjenin p\u00ebrgjegj\u00ebs p\u00ebr plakjen: Hap gjigant p\u00ebr rigjenerimin njer\u00ebzor","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"

\"\"<\/p>\n

Studiuesit kan\u00eb identifikuar procesin q\u00eb shkakton plakjen e l\u00ebkur\u00ebs dhe organeve t\u00eb tjera njer\u00ebzore, n\u00eb at\u00eb q\u00eb mund t\u00eb jet\u00eb nj\u00eb p\u00ebrparim t\u00eb madh p\u00ebr fush\u00ebn e mjek\u00ebsis\u00eb rigjeneruese.<\/span><\/p>\n

P\u00ebrmes \u2018riprogramimit qelizor\u2019, nj\u00eb ekip nga Universiteti i Wisconsin-Madison zbuloi mekanizmin q\u00eb kontrollon plakjen dhe rinimin e qelizave burimore mezenkimale (MSC), i cili mund t\u00eb ndryshoj\u00eb n\u00eb nj\u00eb larmi t\u00eb llojeve t\u00eb ndryshme t\u00eb qelizave, t\u00eb tilla si muskujt ose kockat.<\/span><\/p>\n

Studimi i tyre, i botuar n\u00eb revist\u00ebn Stem Cells t\u00eb h\u00ebn\u00ebn, shton at\u00eb q\u00eb shkenc\u00ebtar\u00ebt tashm\u00eb e dinin se si proceset qelizore shkaktojn\u00eb plakjen e MSC.<\/span><\/p>\n

“Studimi yn\u00eb shkon m\u00eb tej p\u00ebr t\u00eb siguruar pasqyr\u00eb se si MSC t\u00eb riprogramuara rregullohen molekularisht p\u00ebr t\u00eb p\u00ebrmir\u00ebsuar shenjat dalluese qelizore t\u00eb plakjes.”<\/em> – tha nj\u00eb nga bashk\u00ebautor\u00ebt e saj Wan-Ju Li.<\/span><\/p>\n

“Ne besojm\u00eb se gjetjet tona do t\u00eb ndihmojn\u00eb n\u00eb p\u00ebrmir\u00ebsimin e kuptimit t\u00eb plakjes s\u00eb MSC dhe r\u00ebnd\u00ebsin\u00eb e tij n\u00eb mjek\u00ebsin\u00eb rigjeneruese.”<\/em><\/span><\/p>\n

Mjek\u00ebsia rigjeneruese ka t\u00eb b\u00ebj\u00eb me rirritjen, z\u00ebvend\u00ebsimin dhe sh\u00ebrimin e organeve ose indeve t\u00eb d\u00ebmtuara nga mosha dhe s\u00ebmundja.<\/span><\/p>\n

Studiuesit nxorr\u00ebn MSC nga l\u00ebngu sinovial i njeriut, lubrifikant natyral i trupit q\u00eb gjendet rreth nyjeve, duke p\u00ebrfshir\u00eb gjunj\u00ebt dhe b\u00ebrrylat. <\/span><\/p>\n

Ata m\u00eb pas ‘riprogramuan’ MSC n\u00eb nj\u00eb form\u00eb t\u00eb qelizave burimore t\u00eb shnd\u00ebrruara n\u00eb nj\u00eb gjendje t\u00eb ngjashme me embrionin, duke u ofruar shkenc\u00ebtar\u00ebve mund\u00ebsin\u00eb e krijimit t\u00eb ndonj\u00eb qelize brenda trupit t\u00eb t\u00eb rriturve.<\/span><\/p>\n

Ekipi zbuloi se nj\u00eb protein\u00eb (GATA6) ishte shtypur n\u00eb qelizat e ndryshuara t\u00eb MSC, duke \u00e7uar n\u00eb nj\u00eb rritje n\u00eb nj\u00eb protein\u00eb tjet\u00ebr (e njohur si SHH) dhe shprehjen e nj\u00eb proteine \u200b\u200btjet\u00ebr (t\u00eb quajtur FOXP1), e cila \u00ebsht\u00eb aktive n\u00eb zhvillimin e trurit, zemr\u00ebn dhe mushk\u00ebrit\u00eb.<\/span><\/p>\n

Dr Jan Nolta, redaktor i Stem Cells, p\u00ebrsh\u00ebndeti identifikimin e k\u00ebsaj rruge proteine \u200b\u200bn\u00eb kontrollimin e plakjes s\u00eb MSC si nj\u00eb \u2018arritje shum\u00eb e r\u00ebnd\u00ebsishme\u2019.<\/span><\/p>\n

Zbulimi vjen pas nj\u00eb studimi t\u00eb ve\u00e7ant\u00eb t\u00eb koh\u00ebve t\u00eb fundit nga studiuesit n\u00eb Universitetin e Izraelit t\u00eb Tel Aviv, t\u00eb cil\u00ebt pretenduan se kishin p\u00ebrmbysur procesin e plakjes qelizore.<\/span><\/p>\n

Por krahasuar me studimin e Universitetit t\u00eb Wisconsin-Madison, studimi izraelit \u00ebsht\u00eb m\u00eb i diskutuesh\u00ebm p\u00ebr shkak t\u00eb procesit q\u00eb p\u00ebrdori p\u00ebr t\u00eb shkurtuar telomeret – majat e vogla n\u00eb fund t\u00eb secilit kromozom. <\/span><\/p>\n

M\u00eb von\u00eb gjat\u00eb jet\u00ebs, ky proces mund t\u00eb \u00e7oj\u00eb n\u00eb nj\u00eb rrezik n\u00eb rritje t\u00eb s\u00ebmundjeve t\u00eb lidhura me mosh\u00ebn, duke p\u00ebrfshir\u00eb s\u00ebmundjen koronare t\u00eb zemr\u00ebs, diabetin dhe kancerin.<\/span><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"

Studiuesit kan\u00eb identifikuar procesin q\u00eb shkakton plakjen e l\u00ebkur\u00ebs dhe organeve t\u00eb tjera njer\u00ebzore, n\u00eb at\u00eb q\u00eb mund t\u00eb jet\u00eb nj\u00eb p\u00ebrparim t\u00eb madh p\u00ebr fush\u00ebn e mjek\u00ebsis\u00eb rigjeneruese. P\u00ebrmes \u2018riprogramimit qelizor\u2019, nj\u00eb ekip nga Universiteti i Wisconsin-Madison zbuloi mekanizmin q\u00eb kontrollon plakjen dhe rinimin e qelizave burimore mezenkimale (MSC), i cili mund t\u00eb ndryshoj\u00eb […]<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":51,"featured_media":416088,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[53],"tags":[],"class_list":["post-416087","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fast-foodi"],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts\/416087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/users\/51"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/comments?post=416087"}],"version-history":[{"count":0,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/posts\/416087\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/media\/416088"}],"wp:attachment":[{"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/media?parent=416087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/categories?post=416087"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hashtag.al\/index.php\/wp-json\/wp\/v2\/tags?post=416087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}